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Rajanit, Sojitra
- Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Irbesartan and Atorvastatin in Synthetic Mixture
Abstract Views :182 |
PDF Views:2
Authors
Virani Paras
1,
Sojitra Rajanit
1,
Savaj Bhadresh
1,
Raj Hashumati
1,
Jain Vineet
1,
Patel Kalpesh
1,
Sutariya Vishnu
1
Affiliations
1 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 3 (2015), Pagination: 175-181Abstract
A simple, accurate, rapid and precise reverse phase high performance liquid chromatographic method was developed for simultaneous estimation of Irbesartan and Atorvastatin in synthetic mixture. Inertsil C18, 150 mm x 4.6 mm, 5 μm particle size in gradient mode with mobile phase Acetonitrile: 0.1% Formic acid (40: 60 v/v) and pH adjusted to 3.5 ± 0.1 with orthophosphoric acid was used. The flow rate was 1.0 ml/min and absorbance of individual component was measured at 262 nm. The retention times of Irbesartan and Atorvastatin were found to be 3.993 and 7.733 min, respectively. Linearity for Irbesartan and Atorvastatin was in the range of 400 - 800 and 50- 100μg/ml with correlation coefficient values 0.9995and 0.9994, the percentage recovery obtained was 99.88and 99.70 %, respectively.Keywords
Irbesartan, Atorvastatin, RP-HPLC, Method Validation.- Absorption Correction Method for Simultaneous Estimation of Nifedipine and Metoprolol Succinate in Their Synthetic Mixture Using From Spectrophotometry
Abstract Views :207 |
PDF Views:0
Authors
Affiliations
1 Department of Quality Assurance, Shree Dhanvantry Pharmacy College, Kim, Surat, IN
1 Department of Quality Assurance, Shree Dhanvantry Pharmacy College, Kim, Surat, IN